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Leishmania tarentolae as a platform for the production of vaccines against viral pathogens

Welcome new Team Member

Molecular mechanisms of herpesvirus latency and contribution of viral infection to oncogenesis

Development of novel mRNA/VLP-based vaccines against emerging zoonotic viral diseases

Influence of adjuvant type and route of administration on the immunogenicity of Leishmania-derived tick-borne encephalitis virus-like particles – A recombinant vaccine candidate

Welcome new Team Member

Vaccines based on virus-like particles and mRNA

The role of glycosylation of structural proteins in the life cycle of SARS-CoV-2 coronavirus

Alterations in N-glycosylation of HCV E2 protein in children patients with IFN-RBV therapy failure

Poland’s state-of-the-art BSL-3+ laboratory has been officially opened!

Investigation of virus direct transmission, “cell-to-cell” spread mode

The role of O-glycosylation of Zika virus envelope proteins in the replication cycle and its influence on antigenicity

The herpesvirus UL49.5 protein hijacks a cellular C-degron pathway to drive TAP transporter degradation

’This laboratory opens the door to a completely different world for us’. Interview with prof. Krystyna Bieńkowska-Szewczyk

Universal vaccine against SARS-CoV-2 variants based on conserved spike protein epitopes – vaccine efficacy studies in vitro and in vivo

New molecular diagnostic methods and monitoring of microorganism genetic stability

Wild red foxes (Vulpes vulpes) do not participate in SARS-CoV-2 circulation in Poland

BSL3+ lab has just been completed.

Cell-to-cell transmission of SARS-CoV-2

Virus-like particles based on flaviviruses and antiviral activity of synthetic compounds

Hibernating vesper bats are a weak source for biomonitoring of coronaviruses

Congratulations on your PhD – Anna Czarnota

Immunomodulatory properties of SARS-CoV-2 coronavirus-encoded proteins

The mechanisms of virus immune evasion, virus-induced protein degradation, interactions of viruses with extracellular vesicles, and modulation of autophagy

Serological characterisation of Lagovirus virus-like particles originating from native and mutated VP60 of rabbit haemorrhagic disease virus 2 and European brown hare syndrome virus. 

Congratulations on your PhD – Natalia Derewońko

Towards safe anti-SARS-CoV-2 coronavirus vaccine – modifications of the spike protein leading to the elimination of ADE effect.

Construction of experimental bivalent prophylactic vaccine against HBV and HCV

Leucoma salicis nucleopolyhedrovirus (LesaNPV) genome sequence shed new light on the origin of the Alphabaculovirus orpseudotsugatae species

8th European Congress of Virology 2023

Hijacking the ubiquitin-proteasome system by the UL49.5 protein of bovine herpesvirus 1 as an immune evasion strategy – elucidating the mechanismof TAP transporter degradation

Viral infection in the context of regulation of interferon (IFN) signaling

Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies

Congratulations on your PhD – Gabriela Brzuska

Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpesvirus BHV-1

Confocal microscopy imaging in virus studies

An intrinsic network of polar interactions is responsible for binding of UL49.5 C-degron by the CRL2KLHDC3 ubiquitin ligase

Dr Łukasz Rąbalski received an individual award from Minister of Education and Science. Congratulations!

Antiviral activity of interferon induced transmembrane proteins (IFITM) as a novel therapeutic strategy to control viral infections – evaluation in vitro and in vivo

Why does the herpes simplex 1 virus-encoded UL49.5 protein fail to inhibit the TAP-dependent antigen presentation?

Welcome the new Team Member

Mammalian cell delivery of stable therapeutic mRNA packaged inside virus-like particles

Emergence and potential transmission route of avian influenza A (H5N1) virus in domestic cats in Poland.

Congratulations on your PhD – Magda Wąchalska

Evaluation of the immunogenicity of the highly conserved Hepatitis C virus E2 glycoprotein epitopes exposed on the surface of the Hepatitis B small surface antigen virus-like particles

Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2-dependent fashion

Post-doc position at the Laboratory of Virus Molecular Biology

Anti-Zika vaccine – innovative methods for antigen construction

Proteomic response of A549 lung cancer cell line to protein-polysaccharide complex Venetin-1 isolated from earthworm coelomic fluid

Gdańsk City Council highest award for prof. Krystyna Bieńkowska-Szewczyk

Tick-borne encephalitis virus – search for mechanisms useful in treatment and prophylaxis

Computational and enzymatic studies of sartans in SARS-CoV-2 spike RBD-ACE2 binding: the role of tetrazole and perspectives as antihypertensive and COVID-19 therapeutics

Congratulations on your PhD – Kinga Grabowska

Virus-like particles produced in life bioreactors as Vaccine against the most dangerous disease of poultry

The role of PKGIα and AMPK signaling interplay in the regulation of albumin permeability in cultured rat podocytes

Public health risk assessment, associated with potentially dangerous zoonotic influenza A virus strains, circulating among livestock in Poland

Long-time scale simulations of virus-like particles from three human-norovirus strains

Modern Newcastle disease vaccine

The Influence of Adjuvant Type on the Immunogenicity of RBD/N Cocktail Antigens as a Vaccine Candidate against SARS-CoV-2 Virus

The molecular mechanism of activity of alphaherpesvirus-encoded key immune evasion proteins

Characterization of surface-exposed structural loops as insertion sites for foreign antigen delivery in calicivirus-derived VLP platform

Genetic factors causing increased virulence of the baculovirus infectingone of the major forest pests – the gypsy moth (Lymantria dispar)

Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412–425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles

NanoExpo system as a innovative technological process of production of next generation vaccines

Spontaneous mutations in hlyD and tuf genes result in resistance of Dickeya solani IPO 2222 to phage ϕD5 but cause decreased bacterial fitness and virulence in planta

Novel biocontrol agent for use in organic / IPM citrus cultivation: biology, phylogeny and biopesticide activity

Influence of Dosing Regimen and Adjuvant Type on the Immunogenicity of Novel Recombinant Zika Virus-Like Particles

An ecological alternative to excessive chemicalisation of environment. Search and characterization of natural enemies of forest pests

The N-terminal proline hinge motif controls the structure of bovine herpesvirus 1-encoded inhibitor of the transporter associated with antigen processing required for its immunomodulatory function

Influenza vaccine – innovative methods for antigen preparation

Functional characterization and immunogenicity of a novel vaccine candidate against tick-borne encephalitis virus based on Leishmania-derived virus-like particles

Oral vaccine against influenza virus for poultry

In vitro reconstitution reveals a key role of human mitochondrial EXOG in RNA primer processing

Improvement of anvitiral neutralizing antibodies

Characterization of Immune Response towards Generation of Universal Anti-HA-Stalk Antibodies after Immunization of Broiler Hens with Triple H5N1/NA-HA-M1 VLPs.

Mechanisms of virus cell-to-cell spread: virus survival strategies

The influence of tunicamycin analogues and mimetics on hepatitis C virus (HCV) Propagation

The role of IFITM proteins in tick-borne encephalitis virus infection

Correlation between DNA sequence of selected genes of gypsy moth baculovirus (LdMNPV) and their virulence

Mitochondrial DNA Copy Number in Cleavage Stage Human Embryos-Impact on Infertility Outcome

Chimeric virus-like particles presenting tumour-associated MUC1 epitope result in high titers of specific IgG antibodies in the presence of squalene oil-in-water adjuvant: towards safe cancer immunotherapy.

Role of egzosomes in alphaherpesvirus infection

Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans.

New recombinant glycoproteins E1E2 and virus-like particles for vaccines against hepatitis C virus (HCV)

Baculovirus expression and potential diagnostic application of the gp51 envelope glycoprotein of genetic mutants of the bovine leukemia virus.

Biochemical, functional and immunological properties of new recombinant envelope glycoproteins and virus-like particles of hepatitis C virus

Ochrobactrum quorumnocens sp. nov., a quorum quenching bacterium from the potato rhizosphere, and comparative genome analysis with related type strains.

Construction and technological assessment of a vector vaccine against Newcastle disease (ND) in chickens

Production and Biomedical Application of Flavivirus-like Particles. 

Tunicamycin analogues and mimetics as new antiviral agents against different strains of Influenza virus type A”

New Method for Differentiation of Granuloviruses (Betabaculoviruses) Based on Real-Time Polymerase Chain Reaction (Real-Time PCR).

Exploring new immune evasion mechanisms of herpesviruses: the search for improvement strategies of anti-herpesviral vaccines and virus-based therapeutics

High-Titre Neutralizing Antibodies to H1N1 Influenza Virus after Mouse Immunization with Yeast Expressed H1 Antigen: A Promising Influenza Vaccine Candidate. 

Strategies of alphaherpesviruses spread from cell to cell

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus.

Development of biosensor for detection of influenza virus in environmental samples

Selected nucleos(t)ide-based prescribed drugs and their multi-target activity.

Glycosylation inhibitors as new antiviral agents against different strains of Influenza virus type A

Development of a recombinant NP protein based indirect ELISA for the detection of antibodies against Newcastle disease virus and differentiation of infected or recombinant vaccine immunized chickens.

Immunogenic properties of hepatitis C virus NS3 protein epitopes fused to hepatitis B small surface antigen

Research and Development of Biopesticides: Challenges and Prospects.

CENTRE OF MEDICINAL PRODUCT BIOTECHNOLOGY. Package of innovative biopharmaceuticals for human and animal therapy and prophylactics

Genome-Wide Identification of Dickeya solani Transcriptional Units Up-Regulated in Response to Plant Tissues From a Crop-Host Solanum tuberosum and a Weed-Host Solanum dulcamara. 

New preventative and therapeutic Hepatitis C vaccines: from pre-clinical to phase 1, HEPACIVAC

Breath analysis for detection of viral infection, the current position of the field.

New vaccines against Hepatitis C virus (HCV)

Detection and molecular characterisation of SARS-CoV-2 in farmed mink (Neovision vision) in Poland.

Entry inhibitors for the treatment of hepatitis C virus infection (EI-HCV)

Anti-Tick-Borne Encephalitis Virus Activity of Novel Uridine Glycoconjugates Containing Amide or/and 1,2,3-Triazole Moiety in the Linker Structure.

Contribution of immediate- early proteins of pseudorabies virus (PRV; Suid herpes1) to the antiviral protective immune response

Coding-Complete Genome Sequences of Six Influenza Type A Strains Circulating in Lithuania in the 2009–2010 Epidemic Season.

Multifunctional herpesvirus proteins : key elements for vaccine development

High-quality complete genome resource of plant pathogenic bacterium Pectobacterium atrosepticum strain Green1 isolated from potato (Solanum tuberosum L.) in Greenland.

Classical swine fever virus (CSFV) as a model for testing new methods of inhibition of hepatitis C virus (HCV)

Complete genome sequence and phylogenomic analysis of the first N4-like lytic bacteriophage vB_Ppp_A38 (ϕA38) infecting Pectobacterium parmentieri. 

Role of cytoplasmic tails of viral envelope glycoproteins in immune evasion processes of pseudorabies virus”

Usefulness of IVD kits for the assessment of SARS-CoV-2 antibodies to evaluate the humoral response to vaccination.

Expression library immunisation (ELI) designed vaccines against infectious diseases in pigs; rapid identification of immunoprotective antigens and optimal antigen delivery systems

Evaluation of the Presence of ASFV in Wolf Feces Collected from Areas in Poland with ASFV.

Multicomponent and vector vaccines against helminth parasite infections in calves and sheep

Expansion of a SARS-CoV-2 Delta variant with an 872 nt deletion encompassing ORF7a, ORF7b and ORF8, Poland, July to August 2021.

Structural and functional studies of hepatitis C virus glycoproteins: identification of targets for antiviral therapy

Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents.

Low-power microwave-induced fabrication of functionalised few-layer black phosphorus electrodes: a novel route towards Haemophilus Influenzae pathogen biosensing devices.

Humoral response after vaccination with half-dose of BNT162b2 in subjects under 55 years of age.

Humoral response to SARS-CoV-2 vaccine of a patient receiving methotrexate treatment and implications for the need of monitoring.

Severe acute respiratory syndrome coronavirus 2 in farmed mink (Neovison vison), Poland.

Evaluation of the Presence of ASFV in Wolf Feces Collected from Areas in Poland with ASFV Persistence.

Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK.

Inhibition of apoptosis in BHV-1-infected cells depends on Us3 serine/threonine kinase and its enzymatic activity.

HtrA3 is a cellular partner of cytoskeleton proteins and TCP1α chaperonin.

The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes.

Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice.

Antimicrobial blue light photoinactivation of Pseudomonas aeruginosa: Quorum sensing signaling molecules, biofilm formation and pathogenicity.

Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses.

Tetraspanin CD151 impairs heterodimerization of ErbB2/ErbB3 in breast cancer cells.

Anti-Hepatitis C Virus activity of uridine derivatives of 2-deoxy sugars.

Novel Uridine Glycoconjugates, Derivatives of 4-Aminophenyl 1-Thioglycosides, as Potential Antiviral Compounds.

A recombinant turkey herpesvirus expressing F and NH genes of avian avulavirus (AAvV-1) genotype VI confers cross-protection against challenge with virulent AAvV-genotypes IV and VII in chickens

New Method for Differentiation of Granuloviruses (Betabaculoviruses) Based on Multitemperature Single Stranded Conformational Polymorphism.

Isolation and phenotypic and morphological characterization of the first Podoviridae lytic bacteriophages ϕA38 and ϕA41 infecting Pectobacterium parmentieri (former Pectobacterium wasabiae).

Synthesis and preliminary evaluation of biological activity of glycoconjugates analogues of acyclic uridine derivatives.

Morphological, genetic and biological characterisation of a novel alphabaculovirus isolated from Cryptophlebia peltastica(Lepidoptera: Tortricidae).

Bioenergetics of fish spermatozoa with focus on some herring (Clupea harengus) enzymes.

Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics.

Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking.

New oxidovanadium(IV) coordination complex containing 2-methylnitrilotriacetate ligands induces cell cycle arrest and autophagy in human pancreatic ductal adenocarcinoma cell lines.

Interactions of newly synthesized platinum nanoparticles with ICR-191 and their potential application.

The impact of surface functionalization on the biophysical properties of silver nanoparticles.

Cytotoxicity of doxorubicin conjugated with C60 fullerene. Structural and in vitro studies.

The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP)

Cellular substrates and pro-apoptotic function of the human HtrA4 protease

HtrA4 Protease promotes chemotherapeutic-dependent cancer cell death

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

Immunosensor Based on Long-Period Fiber Gratings for Detection of Viruses Causing Gastroenteritis

Metformin reduces TRPC6 expression through AMPK activation and modulates cytoskeleton dynamics in podocytes under diabetic conditions

Alphaherpesvirus gB homologs are targeted to extracellular vesicles, but they differentially affect MHC Class II molecules

Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia

Physicochemical profile of Os (III) complexes with pyrazine derivatives: From solution behavior to DNA binding studies and biological assay

Specific Antibodies Induced by Immunization with Hepatitis B Virus-Like Particles Carrying Hepatitis C Virus Envelope Glycoprotein 2 Epitopes Show Differential Neutralization Efficiency

The PKGIalpha/VASP pathway is involved in insulin- and high glucose-dependent regulation of albumin permeability in cultured rat podocytes.

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region

Palmitoylated mNeonGreen Protein as a Tool for Visualization and Uptake Studies of Extracellular Vesicles

Investigation of the Effects of Primary Structure Modifications within the RRE Motif on the Conformation of Synthetic Bovine Herpesvirus 1-Encoded UL49.5 Protein Fragments

The PKGI alpha-Rac1 pathway is a novel regulator of insulin-dependent glucose uptake in cultured rat podocytes

Identification of a Stable, Non-Canonically Regulated Nrf2 Form in Lung Cancer Cells

Rab-dependent vesicular traffic affects female gametophyte development in Arabidopsis

Antibacterial activity of Co(III) complexes with diamine chelate ligands against a broad spectrum of bacteria with a DNA interaction mechanism.

Immune response against SARS-CoV-2 variants: the role of neutralization assays

Antimicrobial Photodynamic Inactivation Affects the AntibioticSusceptibility of Enterococcus spp. Clinical Isolates in Biofilm and Planktonic Cultures