Grants
2022-2026
The role of glycosylation of structural proteins in the life cycle of SARS-CoV-2 coronavirus
dr hab. Ewelina Król, prof. UG
NCN – OPUS 21
2022-2026
Universal vaccine against SARS-CoV-2 variants based on conserved spike protein epitopes – vaccine efficacy studies in vitro and in vivo
dr Katarzyna Grzyb
NCN – OPUS 21
2022-2024
The role of O-glycosylation of Zika virus envelope proteins in the replication cycle and its influence on antigenicity
mgr Gabriela Brzuska
NCN – PRELUDIUM 20
2021-2027
Development of novel mRNA/VLP-based vaccines against emerging zoonotic viral diseases
prof. Bogusław Szewczyk
The aim of the project is to develop vaccine candidates based on mRNA/VLP technology against one of three zoonotic viral pathogens (SARS-CoV-2 coronavirus, Tick-Borne Encephalitis Virus, TBEV and West Nile virus, WNV) that are of great importance to human health around the world.
The development path started from designing the mRNA encoding for virus antigens, through the potential vaccine candidate evaluation, preclinical and I phase of the clinical studies. The whole project is divided into 10 tasks. They include a research stage using mRNA/VLP technology and a development stage of the production and analysis process on a laboratory and pilot scale.
The suspected project effect combines the advantages of both mRNA and VLPs: high effectiveness, long-lasting, the beginning of the dosing regimen, the possibility of storage in convenient conditions and safety in addition to control and pediatric use.
Project co-financed by the state from the Medical Research Agency, in the competition: Development of new technologies using RNA technology
The consortium consists of: Adamed Sp. Zoo. (Project leader), University of Gdansk and Institute of Biotechnology and Biophysics of the Polish Academy of Sciences
Project value PLN 87,517,519.25, including PLN 11,382,750.00 for UG
Funding PLN 58,494,498.19
Medical Research Agency (ABM)
2021-2025
Immunomodulatory properties of SARS-CoV-2 coronavirus-encoded proteins
dr Andrea Lipińska
NCN – OPUS 20
2021-2025
Cell-to-cell transmission of SARS-CoV-2
prof. dr hab. Krystyna Bieńkowska-Szewczyk
NCN – PRELUDIUM BIS 2
2020-2024
Mammalian cell delivery of stable therapeutic mRNA packaged inside virus-like particles
prof. dr hab. Bogusław Szewczyk
NCN – OPUS 17
2020-2022
Towards safe anti-SARS-CoV-2 coronavirus vaccine – modifications of the spike protein leading to the elimination of ADE effect.
dr hab. Ewelina Król, prof. UG
NCN – Szybka ścieżka dostępu do funduszy na badania nad COVID-19
2020-2022
Hijacking the ubiquitin-proteasome system by the UL49.5 protein of bovine herpesvirus 1 as an immune evasion strategy – elucidating the mechanismof TAP transporter degradation
mgr Magda Wąchalska
NCN – PRELUDIUM 18
2020-2022
Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpesvirus BHV-1
mgr Magda Wąchalska
NCN – ETIUDA 8
2018-2022
Antiviral activity of interferon induced transmembrane proteins (IFITM) as a novel therapeutic strategy to control viral infections – evaluation in vitro and in vivo
dr Alicja Chmielewska
FNP – POWROTY
2018 - 2021
Immunogenic properties of hepatitis C virus NS3 protein epitopes fused to hepatitis B small surface antigen
dr Katarzyna Grzyb
NCN – OPUS 14
2017-2021
Public health risk assessment, associated with potentially dangerous zoonotic influenza A virus strains, circulating among livestock in Poland
dr Krzysztof Łepek
NCN – SONATA 11
2017 - 2020
Anti-Zika vaccine – innovative methods for antigen construction
dr Ewelina Król
NCBiR – LIDER VII
2017 - 2020
Virus-like particles produced in life bioreactors as Vaccine against the most dangerous disease of poultry
dr Łukasz Rąbalski
NCBiR – LIDER VII
2017 - 2020
Evaluation of the immunogenicity of the highly conserved Hepatitis C virus E2 glycoprotein epitopes exposed on the surface of the Hepatitis B small surface antigen virus-like particles
mgr Anna Czarnota
NCN – PRELUDIUM 12
2016-2020
Tick-borne encephalitis virus – search for mechanisms useful in treatment and prophylaxis
dr Ewelina Król
NCN – SONATA 10
2016-2020
Genetic factors causing increased virulence of the baculovirus infectingone of the major forest pests – the gypsy moth (Lymantria dispar)
mgr Martyna Krejmer
NCN – PRELUDIUM 9
2016-2019
Novel biocontrol agent for use in organic / IPM citrus cultivation: biology, phylogeny and biopesticide activity
prof. dr hab. Bogusław Szewczyk
NCBiR – Konkurs na wspólne polsko – południowo afrykańskie projekty badawcze
2016-2019
NanoExpo system as a innovative technological process of production of next generation vaccines
mgr Beata Gromadzka
NCBiR – LIDR VI
2015-2021
The molecular mechanism of activity of alphaherpesvirus-encoded key immune evasion proteins
dr Andrea Lipińska
NCN – SONATA BIS 4
2015-2017
Influenza vaccine – innovative methods for antigen preparation
prof. dr hab. Bogusław Szewczyk
NCBiR – PBS
2015-2016
Modern Newcastle disease vaccine
dr Łukasz Rąbalski
FNP – IMPULS
2015
An ecological alternative to excessive chemicalisation of environment. Search and characterization of natural enemies of forest pests
dr Łukasz Rąbalski
FNP – SKILLS
2013-2017
Oral vaccine against influenza virus for poultry
dr Dawid Nidzworski
NCBiR – LIDER IV
2013-2017
Biochemical, functional and immunological properties of new recombinant envelope glycoproteins and virus-like particles of hepatitis C virus
dr Katarzyna Grzyb
NCN – SONATA 3
2013-2014
Improvement of anvitiral neutralizing antibodies
mgr Krzysztof Lacek
FNP – JUVENTUS PLUS
2012-2018
Mechanisms of virus cell-to-cell spread: virus survival strategies
prof. dr hab. Krystyna Bieńkowska – Szewczyk
NCN – MAESTRO 2
2012-2015
Construction and technological assessment of a vector vaccine against Newcastle disease (ND) in chickens
prof. dr hab. Bogusław Szewczyk
NCBiR – PBS 1
2012-2015
New recombinant glycoproteins E1E2 and virus-like particles for vaccines against hepatitis C virus (HCV)
dr Katarzyna Grzyb
NCBiR – LIDER III
2012-2015
Correlation between DNA sequence of selected genes of gypsy moth baculovirus (LdMNPV) and their virulence
mgr Łukasz Rąbalski
NCN – PRELUDIUM 2
2012-2015
Role of egzosomes in alphaherpesvirus infection
dr Andrea Lipińska
NCN – SONATA 2
2012-2015
The influence of tunicamycin analogues and mimetics on hepatitis C virus (HCV) Propagation
dr Ewelina Król
NCN – PRELUDIUM 2
2011-2014
Exploring new immune evasion mechanisms of herpesviruses: the search for improvement strategies of anti-herpesviral vaccines and virus-based therapeutics
dr Andrea Lipińska
FNP – POMOST
2010-2013
Development of biosensor for detection of influenza virus in environmental samples
mgr Dawid Nidzworski
FNP – VENTURES
2010-2011
Strategies of alphaherpesviruses spread from cell to cell
mgr Agnieszka Brzozowska
FNP – IUVENTUS PLUS
2010-2011
Glycosylation inhibitors as new antiviral agents against different strains of Influenza virus type A
mgr Ewelina Król
FNP – IUVENTUS PLUS
2008-2015
CENTRE OF MEDICINAL PRODUCT BIOTECHNOLOGY. Package of innovative biopharmaceuticals for human and animal therapy and prophylactics
prof. dr hab. Bogusław Szewczyk
MNiSW – POIG
2007-2012
New preventative and therapeutic Hepatitis C vaccines: from pre-clinical to phase 1, HEPACIVAC
prof. dr hab. Krystyna Bieńkowska – Szewczyk,
Coordinator : R. Cortese, Italy
6th EU Framework Program grant, Quality of Life, Priority
2007-2012
New vaccines against Hepatitis C virus (HCV)
prof. dr hab. Krystyna Bieńkowska – Szewczyk
MNiSW SPUB
(co-financing of EU project)
2006-2010
Entry inhibitors for the treatment of hepatitis C virus infection (EI-HCV)
prof. dr hab. Krystyna Bieńkowska – Szewczyk,
Coordinator: J. Ball. UK
6th EU Framework Program grant, Quality of Life,
Marie Curie Research Training Network
2006-2009
Multifunctional herpesvirus proteins : key elements for vaccine development
prof. dr hab. Krystyna Bieńkowska – Szewczyk
MNiSW
2005-2007
Contribution of immediate- early proteins of pseudorabies virus (PRV; Suid herpes1) to the antiviral protective immune response
Collaborating institution: Federal Research Centre for Virus Disease of Animals,
Institute of Immunology, Dr Hanns – Joachim Rziha
Polish – German bilateral collaboration grant
(Ministry of Agriculture)
2004-2007
Classical swine fever virus (CSFV) as a model for testing new methods of inhibition of hepatitis C virus (HCV)
prof. dr hab. Bogusław Szewczyk
Grant KBN
2003-2005
Role of egzosomes in alphaherpesvirus infection
dr Andrea Lipińska
NCN – SONATA 2
2003-2005
Expression library immunisation (ELI) designed vaccines against infectious diseases in pigs; rapid identification of immunoprotective antigens and optimal antigen delivery systems
prof. dr hab. Krystyna Bieńkowska – Szewczyk
5th EU Framework Program grant
2002-2005
Role of cytoplasmic tails of viral envelope glycoproteins in immune evasion processes of pseudorabies virus”
prof. dr hab. Krystyna Bieńkowska – Szewczyk
Collaboration with Ghent University, dr Hans Nauwynck
Polish – Flemish, bilateral coorperation program
Project founded by Flanders government,
research conducted in Poland and Belgium
2002-2005
Structural and functional studies of hepatitis C virus glycoproteins: identification of targets for antiviral therapy
prof. dr hab. Krystyna Bieńkowska – Szewczyk
European Network for Hepatitis C Virus Envelope Glycoprotein Research (ENHCV)
5th EU Framework Program grant
2002-2004
Multicomponent and vector vaccines against helminth parasite infections in calves and sheep
prof. dr hab. Krystyna Bieńkowska – Szewczyk
Grant KBN